| SENS Research Foundation |
SRF Research Scholar |
2016-05-01 |
2016-08-01 |
|
[1] |
Based in Winston Salem, North Carolina, he worked under Dr. John Jackson at the Wake Forest Institute for Regenerative Medicine to investigate the potential of inducing T lymphocyte differentiation ex vivo using bioengineered thymus organoids. The aim was to control T lymphocyte differentiation and potentially enable immuno-modulation by replicating the thymic niche in dynamic culture. He successfully engineered the adult thymic microenvironment and induced T lymphocyte differentiation from primary hematopoietic stem cells. The results suggest that manipulating the adult thymic microenvironment could lead to the development of autologous HSC-derived therapies for hybridized adaptive immune system function. |