Based in Winston Salem, North Carolina, he worked under Dr. John Jackson at the Wake Forest Institute for Regenerative Medicine to investigate the potential of inducing T lymphocyte differentiation ex vivo using bioengineered thymus organoids. The aim was to control T lymphocyte differentiation and potentially enable immuno-modulation by replicating the thymic niche in dynamic culture. He successfully engineered the adult thymic microenvironment and induced T lymphocyte differentiation from primary hematopoietic stem cells. The results suggest that manipulating the adult thymic microenvironment could lead to the development of autologous HSC-derived therapies for hybridized adaptive immune system function.
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